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Destiny 2 Weapon Guide for PvE: What Are the Best Guns to Use

Baako

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Unlike PvP, there isn't much variety in PvE and you don't have to frequently change your combat strategy and weapon configuration. So the best tip is to choose your favorite type of weapon and you should do just fine in most situations. Below is an introduction and analysis of the advantages and disadvantages of different types of weapons in Destiny 2.
 
Pulse Rifle
Semi-auto weapon, triple-shot, and high RPM in all semi-autos.
 
Advantages: it's similar to assault rifle in some ways, and has enhanced ranged damage. It's not as effective as assault rifle in middle and close combat but not unacceptable. It shoots 3 bullets each time and it makes sure you can take down an enemy far away easier.
 
Disadvantages: due to the high RPM and the semi-auto nature, new players may not feel it handy at the beginning. Besides, it's not an effective weapon in middle and close combat.
 
Scout Rifle
Semi-auto weapon, single-shot, suits almost all PvE combat, and No.1 choice for all players.
 
Advantages: it's almost everything you need to play PvE, and the rest thing you need to do is keep a distance with your enemies. Keeping the enemies in a distance means high survivability and more chances for safe kill, and scout rifle and sniper rifle are what you look for. Apparently sniper rifle doesn't fit most combat situations and that makes scout rifle the perfect option. Semi-auto + low firing rate means it's friendly to new players. But it still requires some practice to master the gun.
 
Disadvantages: when you use the optical sight it's not easy to see things near you although you can see things far away clearly. If you miss some enemy nearby, you may fall into a difficult close combat, and scout rifle isn't good at handling close combat.
 
Hand Cannon
Close combat weapon, semi-auto, single-shot, not frequently used in PvE but still becomes the No.2 choice in PvE armory.
 
Advantages: high damage power makes it the second most popular choice for PvE. Once you are in close combat, you can count on hand cannon, which takes care of things for you. If you shoot at the enemy head or weakness, you can take down multiple high level enemies easily with this gun. After all, it's high risk, high reward to go toe-to-toe with enemies with hand cannon but the sense of achievement exactly what attracts more and more players to try close combat.
 
Disadvantages: it's the range, the low capacity and the low firing rate obviously. You can't think of using it to deal with a large group of enemies. You have to be very clear of enemy location when you are in close combat.
 
Side Arm
Semi-auto, single-shot, rarely used in PvE because hand cannon is the better choice.
 
Advantages: higher firing rate and lower recoil compared with hand cannon makes it easier to aim and shoot. In some very little situations in PvE, it's better option than hand cannon.
 
Disadvantages: with lower damage and higher firing rate side arm should have been an alternative to hand cannon, but in most case it's not because of the critical disadvantages it has. Side arm has lower capacity and shorter fire range than hand cannon. If you have a not bad hand cannon you wouldn't think of taking a look at side arm.
 
Submachine Gun

New weapon type in Destiny 2, automatic weapon.
 
Advantages: very high firing rate, possibly effective in middle and close combat.
 
Disadvantages: automatic weapon means high recoil, and it's not good choice for middle and long range combat. If you aren't good at hand cannon, use SMG for close combat.
 
Shotgun
Close combat weapon, semi-auto, can turn the tide in PvP, gets a lot of balances and fixes from Bungie.
 
Advantages: outstanding damage and effective against single enemy near you. Even you can't kill an enemy with a single shot, you can knock back the enemy and make another shot.
 
Disadvantages: super low firing rate and low capacity. Only recommended for 1v1 combat in very short range.
 
Fusion Rifle
Short and middle range weapon, needs a short time to charge before firing.
 
Advantages: like scout rifle, it's effective in long range combat and it can do all things scout rifle can do.
 
Disadvantages: you have to wait for it to charge. The time it takes to charge is depending on the particular gun stat and your character skill and talent. In PvE, you can do well with fusion rifle after you get familiar with the type of gun. Here it comes to prediction because unlike other guns, fusion rifle doesn't shoot after you pull the trigger but starts to charge instead. If you can't predict the enemy you wouldn't be able to shoot at the second you see the enemy. If you don't have a cover for safe charge, you may let the enemy shoot you first.

Sniper Rifle
Shoot enemy boss from long distance, semi-auto, single-shot, No.3 choice in PvE.
 
Advantages: it means death to enemies when they get shot by sniper rifle. It's very effective against boss characters.
 
Disadvantages: it enhances almost every aspect of scout rifle but the inefficiency in close combat makes it not suitable to be used by most players in close combat.
 
Rocket Launcher
Deals area damage, effective against enemy boss, single-shot, No.4 choice in PvE.
 
Advantages: extremely high area damage, can fight multiple enemies and boss characters. Doesn't require you to aim carefully.
 
Disadvantages: can damage players themselves if they aren't careful, especially in close combat. Low capacity requires you to use this weapon wisely. Only save it for enemy boss unless you are cornered by a large group of enemies.

Linear Fusion Rifle
Effective against bosses, needs to charge before shooting, a gun every Guardian dreamed of.
 
Advantages: unlike rocket launcher, LFR can have damage bonus when hitting the bosses' weak points. You can deal a huge amount of damage when you make a headshot.
 
Disadvantages: regardless of the hideously high damage, the weapon is actually not that good in your hands. First of all, it needs to be charged first just like fusion rifle. Then it's the very thin beam it fires (fusion rifle fires 7 distinct beams but LFR just fires one) requires you to aim very carefully in order to not miss the target. When you have to aim very carefully, you can't deal really a lot of damage.
 
Grenade Launcher
New weapon type for Destiny 2, single-shot, deals area damage like rocket launcher.
 
Advantages: higher capacity and firing rate than rocket launcher; can use it to fight pawns and bosses without worrying too much about the ammo.
 
Disadvantages: lower damage than rocket launcher. It has to hit the enemy to explode immediately, meaning if you hit the ground, you may miss the target.
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